Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation

Figure 4

Ebselen reversed the CIH-induced increase in BP responses evoked by an acute hypoxic stimulus. Telemetry recordings realized in the same rat show the pressure response evoked by hypoxia (5% O₂ for 50 s), during sham conditions, after 7 days of CIH, and after additional 7 days of CIH but supplemented with Ebselen (a). Summary of the effect of Ebselen on mean arterial blood pressure (MABP, (b)) and heart rate (HR, (c)). , CIH versus sham and Ebselen CIH, and Newman-Keuls after Repeated Measures ANOVA, rats.

(a)

(b)

(c)