TY - JOUR A2 - Dal Pizzol, Felipe AU - Cristóvão, Joana S. AU - Santos, Renata AU - Gomes, Cláudio M. PY - 2016 DA - 2016/01/10 TI - Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease SP - 9812178 VL - 2016 AB - Alzheimer’s disease (AD) is the most prevalent age-related dementia affecting millions of people worldwide. Its main pathological hallmark feature is the formation of insoluble protein deposits of amyloid-β and hyperphosphorylated tau protein into extracellular plaques and intracellular neurofibrillary tangles, respectively. Many of the mechanistic details of this process remain unknown, but a well-established consequence of protein aggregation is synapse dysfunction and neuronal loss in the AD brain. Different pathways including mitochondrial dysfunction, oxidative stress, inflammation, and metal metabolism have been suggested to be implicated in this process. In particular, a body of evidence suggests that neuronal metal ions such as copper, zinc, and iron play important roles in brain function in health and disease states and altered homeostasis and distribution as a common feature across different neurodegenerative diseases and aging. In this focused review, we overview neuronal proteins that are involved in AD and whose metal binding properties may underlie important biochemical and regulatory processes occurring in the brain during the AD pathophysiological process. SN - 1942-0900 UR - https://doi.org/10.1155/2016/9812178 DO - 10.1155/2016/9812178 JF - Oxidative Medicine and Cellular Longevity PB - Hindawi Publishing Corporation KW - ER -