Potential Modulation of Sirtuins by Oxidative Stress

Figure 1

Structure of sirtuins. (a) Crystal structure of a partial sequence of hSIRT1 (PDB 4KXQ) with bound substrates, acetylated peptide, and NAD. The catalytic core is depicted in yellow with the Zn²⁺ binding domain. (b) Zoom of catalytic site with the catalytic histidine colored in yellow.

(a)

(b)