Reduced HMGB 1-Mediated Pathway and Oxidative Stress in Resveratrol-Treated Diabetic Mice: A Possible Mechanism of Cardioprotection of Resveratrol in Diabetes Mellitus

Figure 1

Resveratrol regulated HMGB 1 in serum and monocytes. (a) Resveratrol reduced the secretion of HMGB 1 to serum. (b) Resveratrol downregulated HMGB 1 expression in monocytes. Number of animals: 8 per group. versus N group; versus N group; versus DM group; versus DM group. HMGB 1: high mobility group box-1; N: normal mice; DM: diabetic mice; DMR5: diabetic mice with 5 mg/kg/day resveratrol treatment; DMR25: diabetic mice with 25 mg/kg/day resveratrol treatment.

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