Oxidative Medicine and Cellular Longevity / 2016 / Article / Fig 2

Research Article

Reduced HMGB 1-Mediated Pathway and Oxidative Stress in Resveratrol-Treated Diabetic Mice: A Possible Mechanism of Cardioprotection of Resveratrol in Diabetes Mellitus

Figure 2

Western blot analysis of HMGB 1, RAGE, TLR4, and NF-κB proteins in hearts of four groups. (a) Representative immunoblots of HMGB 1, RAGE, TLR4, and NF-κB in four groups. ((b)–(e)) Protein analysis of HMGB 1, RAGE, TLR4, and NF-κB. Number of animals: 8 per group. versus N group; versus N group; versus DM group; versus DM group. HMGB 1; high mobility group box-1; RAGE: receptor for advanced glycation end products; TLR4: toll-like receptor 4; NF-κB: nuclear factor κB; N: normal mice; DM: diabetic mice; DMR5: diabetic mice with 5 mg/kg/day resveratrol treatment; DMR25: diabetic mice with 25 mg/kg/day resveratrol treatment.

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