Oxidative Medicine and Cellular Longevity / 2016 / Article / Fig 3

Research Article

Reduced HMGB 1-Mediated Pathway and Oxidative Stress in Resveratrol-Treated Diabetic Mice: A Possible Mechanism of Cardioprotection of Resveratrol in Diabetes Mellitus

Figure 3

Effects of resveratrol on DM-induced oxidative stress. ((a)–(d)) Western blot analysis of p66shc, p47phox, and gp91phox levels in four groups. ((e), (f)) Observation of ROS by DHE staining in heart sections. Number of animals: 8 per group. versus N group; versus N group; versus DM group; versus DM group. Bar = 50 μm. DHE: dihydroethidium; N: normal mice; DM: diabetic mice; DMR5: diabetic mice with 5 mg/kg/day resveratrol treatment; DMR25: diabetic mice with 25 mg/kg/day resveratrol treatment.

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