Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer

Table 3

Carcinogenic role of carbonyl compounds.

Diseases/genotoxicity	Species	Carbonyl association	References
Colitis-associated colorectal neoplasms	Mice	Coupled with high carbonyl levels, for example, malondialdehyde	[19, 153]
Stomach hyperplasia, squamous papilloma, and carcinoma	Rats	2,4-Hexadienal exposure	[73]
Precancerous gastritis and gastric cancer	Humans	High serum malondialdehyde levels	[154, 155]
Colorectal cancer	Humans	High serum lipid peroxide levels	[156]
Colon and gastric cancers	Humans	Acetaldehyde from alcohol	[69, 70]
Colorectal adenocarcinoma	Humans	High protein carbonyl levels	[157]
Precancerous colorectal adenopolyps	Humans	High protein carbonyl levels	[158]
Colorectal cancer	Humans	High lipid peroxide levels in tissues	[159–161]
Genotoxicity	Humans	High carbonyl DNA adduct levels in tissues	[58, 162, 163]
Genotoxicity	Cell lines/in vitro studies	Production of carbonyl DNA adducts	[164–167]