Liver Cholesterol Overload Aggravates Obstructive Cholestasis by Inducing Oxidative Stress and Premature Death in Mice

Figure 3

Cholesterol overload exacerbates liver tissue damage. Histology analysis by H&E staining. Liver tissue was obtained from animals fed with standard Chow control diet (Chow) or high cholesterol (HC) diet for 2 days and subjected to BDL. Bridging hepatic necrosis areas (asterisks), polymorphonuclear leukocytes and lymphocytes infiltration (black arrow head), inflammatory cells infiltration (arrow), and cell proliferation (white arrow head). Representative images from at least four different animals. Original magnification: 200x.

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