Functionalized Fullerene Increases NF-<i>κ</i>B Activity and Blocks Genotoxic Effect of Oxidative Stress in Serum-Starving Human Embryo Lung Diploid Fibroblasts

<div>F-828 reduces NRF2 in serum-starving HELFs. (a) (FCA): (1): the FL1-NRF2 versus SSC plots. Gate R encircles the fraction of HELFs with elevated values of FL1-NRF2; (2): dependence of the median values of FL1-NRF2 signals on the fullerene concentrations. (b) (qRT-PCR): changes in the levels of mRNAs encoding<i> NRF2</i> and<i> KEAP1</i> in HELFs.</div>

Oxidative Medicine and Cellular Longevity

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Figure 8

Figure 8: Functionalized Fullerene Increases NF-<i>κ</i>B Activity and Blocks Genotoxic Effect of Oxidative Stress in Serum-Starving Human Embryo Lung Diploid Fibroblasts 

Figure 8 | Functionalized Fullerene Increases NF-κB Activity and Blocks Genotoxic Effect of Oxidative Stress in Serum-Starving Human Embryo Lung Diploid Fibroblasts 