The Significance of Hypothiocyanite Production via the Pendrin/DUOX/Peroxidase Pathway in the Pathogenesis of Asthma

Table 2

Effects of peroxidase inhibitor and genetic deficiency of each peroxidase on asthma model mice (referred from [10]).

Phenotype	Met-L	Met-S	Lpo^−	Epx^−	Mpo^−
AHR	↓↓↓	↓↓	↓	↓	→
BALF
Eosinophil	↓↓↓	↓↓	↓↓	→	→
T cell	↓↓↓	↓	↓↓	↓	→
Neutrophil	↓↓↓	↓↓	↓	→	→
Macrophage	→	→	↓	→	→

Effects of the long (Met-L) or short (Met-S) administration of methimazole or genetic deficiency of Lpo (Lpo⁻), Epx (Epx⁻), and Mpo (Mpo⁻) on enhanced AHR and the numbers of eosinophils, T cells, neutrophils, and macrophages in BALF of asthma model mice are depicted.