Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats
Simvastatin inhibits inflammation and myocardial apoptosis in STZ-induced diabetic rats. Simvastatin decreased serum levels of (a) TNF-α and (b) CRP and (c) NF-κB p65 expression in the heart of diabetic rats. Data are M ± SEM (). . STZ: streptozotocin; SIM: simvastatin; TNF-α: tumor necrosis factor alpha; CRP: C-reactive protein; NF-κB: nuclear factor kappaB; ns: nonsignificant. (d) Photomicrographs of caspase-3 immunostained sections in the heart of (A) control rats, (B) normal rats treated with simvastatin showing immune-negative reaction (arrow), (C) STZ-induced diabetic rats showing strong immunopositive reaction in many myocardial cells (arrows), and (D) diabetic rats treated with simvastatin showing marked decrease in caspase-3 immune-positivity of the myocardial cells (arrow).
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