Testosterone Upregulates the Expression of Mitochondrial ND1 and ND4 and Alleviates the Oxidative Damage to the Nigrostriatal Dopaminergic System in Orchiectomized Rats

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td class="align_left">Analyte</td><td class="align_center"><i>r</i></td><td class="align_center">LLOQ (ng/g)</td><td class="align_center">Recovery (%)</td><td class="align_center">Intraprecision (RSD %)</td><td class="align_center">Interprecision (RSD %)</td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td class="align_left">DA</td><td class="align_center">0.9969</td><td class="align_center">2.0</td><td class="align_center">94.6 ± 8.7</td><td class="align_center">10.3</td><td class="align_center">12.4</td></tr><tr><td class="align_left">DOPAC</td><td class="align_center">0.9982</td><td class="align_center">72.0</td><td class="align_center">93.4 ± 6.6</td><td class="align_center">8.9</td><td class="align_center">7.5</td></tr><tr><td class="align_left">HVA</td><td class="align_center">0.9977</td><td class="align_center">50.0</td><td class="align_center">95.3 ± 7.4</td><td class="align_center">7.7</td><td class="align_center">11.3</td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>DA: dopamine; DOPAC: 3,4-dihydroxyphenylacetic acid; HVA: homovanillic acid.<br/></td></tr></table>

Validation parameters of the LC-MS/MS method.

Oxidative Medicine and Cellular Longevity

tab1

Table 1

Table 1: Testosterone Upregulates the Expression of Mitochondrial ND1 and ND4 and Alleviates the Oxidative Damage to the Nigrostriatal Dopaminergic System in Orchiectomized Rats 

Table 1 | Testosterone Upregulates the Expression of Mitochondrial ND1 and ND4 and Alleviates the Oxidative Damage to the Nigrostriatal Dopaminergic System in Orchiectomized Rats 