Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation

Table 1

Effect of probucol on serum MDA and antioxidant enzyme activities 12 hours after ROSC (; ).

Group	MDA (mmol/l)	CAT (U/l)	GPx (U/l)	GSH (U/l)	SOD (U/l)
Sham operated	1.16 ± 0.12	2.32 ± 0.76	1.62 ± 0.47	1.47 ± 0.45	1.80 ± 0.43
CA model	3.07 ± 0.67	0.97 ± 0.32	0.75 ± 0.23	0.65 ± 0.10	0.75 ± 0.21
CA + low dose	2.98 ± 0.93	1.04 ± 0.43	1.11 ± 0.61^†	0.83 ± 0.25	1.03 ± 0.31^†
CA + medium dose	1.94 ± 0.45^‡§	1.77 ± 0.55^‡§	1.42 ± 0.40^‡	1.04 ± 0.52^†§	1.33 ± 0.53^†
CA + high dose	1.45 ± 0.46^‡¶††	2.02 ± 0.74^‡¶††	1.50 ± 0.35^‡§	1.28 ± 0.40^‡§	1.49 ± 0.35^‡§

versus the sham-operated group; ^† and ^‡ versus the animal CA model group; ^§ and ^¶ versus the low-dose group; ^†† versus the medium-dose group. CAT: catalase; GPx: glutathione peroxidase; GSH: glutathione; MAD: malondialdehyde; ROSC: return of spontaneous circulation; SOD: superoxide dismutase.