Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation

Table 4

Effect of probucol on myocardial function 12 hours after ROSC (; ).

Group	LVESD/mm	LVEDD/mm	LVEF (%)	Short-axis shortening (%)
Sham operated	3.31 ± 0.31	4.57 ± 0.54	83.23 ± 3.80	50.54 ± 3.14
CA model	5.27 ± 1.01	7.98 ± 0.64	62.78 ± 4.30	36.25 ± 2.42
CA + low dose	5.02 ± 0.78	6.76 ± 0.13^†	65.74 ± 4.21	37.59 ± 2.51
CA + medium dose	4.50 ± 0.21^†	5.89 ± 0.59^‡	68.43 ± 2.96^†	41.45 ± 3.49^†§
CA + high dose	3.27 ± 0.56^‡¶††	4.94 ± 0.70^‡§††	73.29 ± 2.08^‡¶††	48.81 ± 3.45^‡¶††

versus the sham-operated group; ^† and ^‡ versus the animal model group; ^§ and ^¶ versus the low-dose group; ^†† versus the medium-dose group. LVEDD: left ventricular end-diastolic diameter; LVEF: left ventricular ejection fraction; LVESD: left ventricular end-systolic diameter; ROSC: return of spontaneous circulation.