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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 1320241, 14 pages
Research Article

Oxidative Phosphorylation System in Gastric Carcinomas and Gastritis

1Laura-Bassi Centre of Expertise, Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, 5020 Salzburg, Austria
2Institute of Pathology, Paracelsus Medical University, 5020 Salzburg, Austria
3Division of Molecular Biology, Department of Microbiology, Paris-Lodron University, 5020 Salzburg, Austria
4Department of Medicine and Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine and Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37232, USA
5Department of Pediatrics, Paracelsus Medical University, 5020 Salzburg, Austria

Correspondence should be addressed to René G. Feichtinger; ta.klas@regnithcief.r

Received 31 January 2017; Revised 10 April 2017; Accepted 10 May 2017; Published 28 June 2017

Academic Editor: Maik Hüttemann

Copyright © 2017 René G. Feichtinger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary figure 1: (A) Complex II in normal adjacent tissue. (B) Complex II in intestinal gastric carcinoma (C) Complex V in normal adjacent tissue. (D) Complex V in tumor tissue. (Case M14). In A and C again parietal cells are visible (dark brown staining). Magnification 10x. Supplementary figure 2: Immunohistochemical staining of the OXPHOS complexes of normal tissue. (A-C; G-I) Diffuse gastric carcinoma; (D-F; J-L) Tumor tissue. (A,D) Porin; (B,E) complex I; (C,F) complex II; (G,J) complex III; (H,K) complex IV; (I,L) Complex V. (Case M39) Magnification 10x. Supplementary table 1: Primers used for amplification and sequencing of mtDNA. Supplementary table 2: Clinical charateristics including tumor classification. Supplementary table 3: Influence of clinico-pathological parameters on expression of mitochondrial proteins. Supplementary table 4 - Part F Score values for complex V in intestinal gastric carcinoma. Supplementary table 5 - Part F Score values for complex V in diffuse gastric carcinoma.

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