Rat Liver Enzyme Release Depends on Blood Flow-Bearing Physical Forces Acting in Endothelium Glycocalyx rather than on Liver Damage

Figure 5

Effects of calcium and of gadolinium (inhibitor of stretch-sensitive channels) on enzyme release by livers from control and PH rats after increasing the perfusion rate. Results of enzyme activities are expressed as mean ± SE (six independent determinations per experimental point) as mUnits⋅min⁻¹⋅g⁻¹ of liver for LDH, ALT, GDH, and OCT. Additions to the perfusion medium were 1.8 mmol/L calcium and gadolinium chloride (0.1 to 10 moles/L). Symbols for each experimental condition are indicated at the top of the figure.