Collaborative Power of Nrf2 and PPARγ Activators against Metabolic and Drug-Induced Oxidative Injury

Figure 1

Crosstalk between Nrf2 and PPARγ pathways against oxidative stress. Abbreviations used within the figure are as follows. Nrf2; nuclear factor erythroid 2-related factor 2, KEAP1; Kelch-like ECH-associated protein 1, CUL3; cullin3, PPARγ; peroxisome proliferator-activated receptor γ, HO-1; heme oxygenase-1, NQO-1; NAD(P)H quinone oxidoreductase-1, GST; glutathione, γ-GCL; γ-glutamyl cysteine ligase, SOD; superoxide dismutase, CAT; catalase, GPX; glutathione peroxidase, AREs; anti-oxidant response elements, MnSOD; manganese superoxide dismutase, PPREs; PPAR response element, RXR; retinoid X receptor.