Baicalin Attenuates Subarachnoid Hemorrhagic Brain Injury by Modulating Blood-Brain Barrier Disruption, Inflammation, and Oxidative Damage in Mice

Figure 7

Schematic diagram of baicalin-mediated protection in SAH mice. SAH injury in brain leads to three physiological responses, namely, inflammation, microglial cell activation, and oxidative damage, which lead to cellular injury and cell death. Baicalin modulates all three physiological processes and thus attenuated SAH-mediated brain injury. Baicalin also restores blood-brain barrier function impaired by SAH, where degradation of tight junction proteins was modulated.