Review Article
Resistance to mTORC1 Inhibitors in Cancer Therapy: From Kinase Mutations to Intratumoral Heterogeneity of Kinase Activity
Figure 1
mTORC1 regulates cellular anabolic processes. mTORC1 is activated by growth promoting conditions including energy, nutrients, and growth factors. In contrast, unfavorable conditions such as hypoxia or acidity inhibit mTORC1. Once activated, mTORC1 promotes key anabolic processes that lead to cell growth. In addition, mTORC1 inhibits autophagy. A nonexhaustive list of downstream effectors of mTORC1 is displayed.