Apolipoprotein CIII Overexpression-Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death

Figure 10

Effects of fenofibrate treatment on high-fat-diet-induced inflammation and apoptosis. (a) Liver cleaved caspase-1 (), (b) liver IL1ββ (), (c) liver BCL2/BAX ratio ( = 7–9), (d) liver cleaved caspase-3 () and number of apoptotic cells (TUNEL-positive cells), and (c) representative images and (d) quantification () from NTg and apoCIII mice fed either a low-fat (LF) or high-fat (HF) diets for 16 weeks. Data are expressed as the mean ± SEM. versus HF group; versus apoCIII mice (; two-way ANOVA). values with nonmatching superscript letters are significantly different (; ANOVA followed by Bonferroni correction).

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