Apolipoprotein CIII Overexpression-Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death

Table 5

Plasma indicators of liver injury and inflammation, liver triglyceride content, oxidative stress indicators, and gene expression related to energy metabolism in NTg and CIII mice fed a high-fat diet (HFD) with or without fenofibrate treatment (HFD/F).

	HFD		HFD/F
	NTg	CIII	NTg	CIII
Plasma AST (U/L)
	(5)	(5)	(5)	(5)
Plasma ALT (U/L)
	(5)	(5)	(4)	(4)
Plasma adiponectin (ng/mL)
	(5)	(5)	(5)	(6)
Plasma TNFα (pg/mL)
	(4)	(4)	(4)	(4)
Plasma IL6 (pg/mL)
	(5)	(5)	(5)	(5)
Plasma C-reactive protein (ng/mL)
	(5)	(5)	(5)	(5)
Plasma IL1β (pg/mL)
	(4)	(4)	(4)	(5)
Liver triglycerides (mg/g)
	(7)	(8)	(6)	(6)
Liver GSSG/GSH ratio
	(6)	(6)	(6)	(6)
Liver protein carbonyl (nmol/mg protein)
	(6)	(7)	(6)	(6)
Liver mRNA (% control)
PPARα
	(5)	(6)	(5)	(6)
FAS
	(8)	(5)	(5)	(5)
CPT1
	(8)	(8)	(6)	(6)
ACO
	(6)	(6)	(6)	(6)
UCP2
	(6)	(5)	(5)	(5)
Adiponectin R2
	(8)	(6)	(6)	(6)

mRNA data normalized to beta-actin. Mean ± SEM () versus HFD/F groups and versus apoCIII mice (; two-way ANOVA). values with nonmatching superscript letters are significantly different (, ANOVA followed by Bonferroni correction).