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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 1956104, 13 pages
Research Article

Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice

1Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu, Japan
2School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
3Department of Ophthalmology, Institute for Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
4Laboratory of Biomedical Cell Technologies, School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia
5Division of Disease Control and Molecular Epidemiology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu, Japan
6The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido, Tobetsu, Japan
7Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
8Health Care Laboratory, FUJIFILM Corporation, Tokyo, Japan
9Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan
10Department of Dentistry, Lotung Poh-Ai Hospital, Yilan, Taiwan
11Department of Ophthalmology, Health Sciences University of Hokkaido Hospital, Sapporo, Japan

Correspondence should be addressed to Nobuyoshi Kitaichi;

Received 2 April 2017; Revised 14 June 2017; Accepted 25 July 2017; Published 28 September 2017

Academic Editor: Xiaolun Sun

Copyright © 2017 Fumiya Harada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table 1: Corneal epithelial thickness, 24 hours after UVB exposure, when treated with different doses of Nano-AST. Supplementary Table 2: Comparison of Nano-AST to other antioxidant treatments. Supplementary Table 3: Mean grey value DHE (ROS) staining in cornea. Supplementary Table 4: Quantification of TUNEL positive cells. Supplementary Table 5: Quantification of NF-?B positive nuclei. Supplementary Table 6: Quantification of COX-2 positive cells ratio. Supplementary Table 7: Quantitative PCR analysis of TNFa expression in the mouse cornea.

  1. Supplementary material