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Oxidative Medicine and Cellular Longevity
Volume 2017 (2017), Article ID 2326178, 9 pages
https://doi.org/10.1155/2017/2326178
Review Article

Nrf2, a Potential Therapeutic Target against Oxidative Stress in Corneal Diseases

1Department of Ophthalmology, The First Hospital of Jilin University, Jilin, China
2Department of Radiology, The First Hospital of Jilin University, Jilin, China
3Department of Neurosurgery, The People’s Hospital of Jilin Province, Jilin, China
4Department of Gastroenterology, The First Hospital of Jilin University, Jilin, China
5Department of Cardiology, The First Hospital of Jiamusi University, Heilongjiang, China
6Translational Medicine Research Institute, The First Hospital of Jilin University, Jilin, China
7Department of Obstetrics and Gynecology, The First Hospital of Jilin University, Jilin, China

Correspondence should be addressed to Cheng-Wei Lu and Ji-Long Hao

Received 3 April 2017; Accepted 20 September 2017; Published 25 October 2017

Academic Editor: Marina Sokovic

Copyright © 2017 Xiu-Fen Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Corneal diseases are one of the major causes of blindness worldwide. Conservative medical agents, which may prevent sight-threatening corneal disease progression, are urgently desired. Numerous evidences have revealed the involvement of oxidative stress in various corneal diseases, such as corneal wound healing and Fuchs endothelial corneal dystrophy (FECD). Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like erythroid-cell-derived protein with CNC homology- (ECH-) associated protein 1 (Keap1)/antioxidant response element (ARE) signaling is well known as one of the main antioxidative defense systems. To the best of our knowledge, this is the first review to elucidate the different expression profiles of Nrf2 signaling as well as the underlying mechanisms in corneal diseases, implicating that Nrf2 may serve as a potentially promising therapeutic target for corneal diseases.