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Oxidative Medicine and Cellular Longevity
Volume 2017 (2017), Article ID 2391820, 9 pages
https://doi.org/10.1155/2017/2391820
Research Article

The Preconditioning of Berberine Suppresses Hydrogen Peroxide-Induced Premature Senescence via Regulation of Sirtuin 1

1Department of Clinical Immunology, Research Center for Immunology, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang 453003, China
2Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang 453003, China
3Xinxiang Assegai Medical Laboratory Institute, Xinxiang Medical University, Xinxiang 453003, China
4Department of Microbiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China

Correspondence should be addressed to Xiaofei Zhu; nc.ude.umxx@fxuhz

Received 20 April 2017; Accepted 23 May 2017; Published 2 July 2017

Academic Editor: Isabel C. F. R. Ferreira

Copyright © 2017 Xiaofei Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure. S1 Protective effect of BBR on H2O2-induced growth inhibition in human diploid fibroblasts. * p<0.05, * * p<0.01.The results are representative of three separate experiments. Figure. S2 the expression level of SIRT1 in low concentration BBR-treated human diploid fibroblasts. 2BS cells were treated with 12μmol/L BBR for indicated time, then total protein was collected and detected SIRT1 by Western Blotting A: expression of SIRT1 in a time-dependent manner. B: Relative expression levels of Sirt1 by gray analysis. * p<0.05, * * p<0.01.The results are representative of three separate experiments.

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