MicroRNA Regulation of Oxidative Stress-Induced Cellular Senescence

Figure 3

MicroRNAs and their mRNA targets as modulators of redox biology, mitochondrial metabolism, and quality control of DNA and proteins. The maintenance of DNA and protein quality is crucial for the preservation of youthful physiology in animals. Accordingly, mechanisms of DNA and protein quality control (QC) were identified as key targets for cellular senescence and aging. The performance of both QC mechanisms is affected by both mitochondrial and cytosolic ROS. Depicted here are known functions of microRNAs as mediators between ROS production and QC mechanisms. The final outcome of this regulatory circuit is further modulated by other (additional) mechanisms which are currently incompletely understood.