Obesity Downregulates MicroRNA-126 Inducing Capillary Rarefaction in Skeletal Muscle: Effects of Aerobic Exercise Training

Figure 6

Schematic presentation of swimming training effects on skeletal muscle angiogenesis by miRNA-126. Obesity reduces the miRNA-126 expression leading an increase of PI3KR2, blocking the VEGF pathway, thereby contributing to the phenotype of capillary rarefaction in skeletal muscle. However ET increases miRNA-126 expression improving the VEGF pathway promoting angiogenesis.