Research Article
Roles of Endoplasmic Reticulum Stress in NECA-Induced Cardioprotection against Ischemia/Reperfusion Injury
Figure 5
NECA induces cardioprotection by inactivating GSK-3β via ERS and cGMP/PKG signaling pathway. (a) NECA (0.1 μM) increased GSK-3β and VASP phosphorylation and decreased GRP94 expression, the effect that was reversed by the specific inducer of PKG KT5823 (1 μM). (b, c, d) Data are mean ± SD for 8 independent experiments performed in duplicate. compared to the control group; compared to NECA.
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