In Vivo Radioprotective Activity of Cell-Permeable Bifunctional Antioxidant Enzyme GST-TAT-SOD against Whole-Body Ionizing Irradiation in Mice

Table 2

The effect of GST-TAT-SOD on the hepatic antioxidant activity of irradiated mice.

	MDA; (nmol/mg protein)	SOD activity; (U/mg protein)	GST activity; (U/mg protein)
CON	0.95 ± 0.50	1112.52 ± 220.08	23.75 ± 2.52
GST-TAT-SOD	1.05 ± 0.32	954.22 ± 260.04	21.49 ± 6.96
XRT	1.90 ± 0.34^#	840.47 ± 140.48^##	20.50 ± 4.00
XRT + AMFT	0.91 ± 0.44	906.62 ± 168.83	21.82 ± 4.84
XRT + GST-TAT-SOD	0.71 ± 0.14	1123.21 ± 289.10	22.81 ± 8.27

Animals were sacrificed 7 days after 6 Gy whole-body irradiation. Then, the liver was collected and homogenized. The hepatic antioxidant activity was determined spectrophotometrically using their corresponding diagnostic reagent kits according to the manufacturer’s instructions. Values are expressed as means ± SD (; compared with control group, ^#, ^##, compared with XRT group, , ).