Protein Glutathionylation in the Pathogenesis of Neurodegenerative Diseases

Figure 1

Proposed mechanisms for specific-protein glutathionylation/deglutathionylation in the pathogenesis of several neurodegenerative diseases. Glutathionylation of GAPDH can lead to a decrease in the enzymatic activity. This process can contribute to accumulation of Aβ and induce AD. Additionally, glutathionylation of TRPC5 triggers increased calcium uptake leading to apoptotic cell death and contributes to the pathogenesis of HD. Decreased glutathionylation of ATP synthase β subunit can inhibit enzymatic activity of mitochondrial ATP synthase. This alteration affects mitochondrial function and can contribute to the development of PD.