Protein Glutathionylation in the Pathogenesis of Neurodegenerative Diseases

Table 1

Summary of the glutathionylated proteins involved in neurodegenerative diseases.

Disease	Target protein of glutathionylation	Effect of glutathionylation	Reference
AD	Glyceraldehyde-3-phosphate dehydrogenase	Inhibition of α-enolase activity	[58]
	p53	Possibly prevention of its tetramer formation	[60]
	α-Enolase	Inactivation	[58]
PD	Mitochondrial NADP^+-dependent isocitrate dehydrogenase	Inhibition of its activity	[85]
	ATP synthase β subunit	Possible regulation of complex V assembly	[86]
HD	TRPC5	Activation of Ca^2+ channel	[105]