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Oxidative Medicine and Cellular Longevity
Volume 2017 (2017), Article ID 2867630, 12 pages
https://doi.org/10.1155/2017/2867630
Research Article

An Alginate/Cyclodextrin Spray Drying Matrix to Improve Shelf Life and Antioxidant Efficiency of a Blood Orange By-Product Extract Rich in Polyphenols: MMPs Inhibition and Antiglycation Activity in Dysmetabolic Diseases

1Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano, Italy
2Department of Drug Science, University of Catania, Viale A. Doria, 95100 Catania, Italy
3Department of Agricultural and Forest Sciences, University of Palermo, Viale delle Scienze Ed.4, 90128 Palermo, Italy
4Consiglio per la Ricerca in Agricoltura e l’Analisi dell’Economia Agraria (CREA) – Centro di ricerca Olivicoltura, Frutticoltura e Agrumicoltura, Corso Savoia, 190, 95024 Acireale, Italy

Correspondence should be addressed to Maria Rosaria Lauro; ti.asinu@orual

Received 30 June 2017; Accepted 20 September 2017; Published 2 November 2017

Academic Editor: Anna V. Queralt

Copyright © 2017 Maria Rosaria Lauro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. M. Galanakis, “Recovery of high added-value components from food wastes: conventional, emerging technologies and commercialized applications,” Trends in Food Science & Technology, vol. 26, pp. 68–87, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Rapisarda, S. E. Bellomo, and F. Intrigliolo, “Anthocyanins in blood oranges: composition and biological activity,” in Recent Research Developments in Agricultural and Food Chemistry, S. G. Pandalai, Ed., vol. 5, pp. 217–230, Research Signpost, Trivandrum, India, 2001. View at Google Scholar
  3. P. Rapisarda, A. Tomaino, R. Lo Cascio, F. Bonina, A. De Pasquale, and A. Saijia, “Antioxidant effectiveness as influenced by phenolic content of fresh orange juices,” Journal of Agricultural and Food Science, vol. 47, pp. 4718–4723, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Rapisarda, S. Fabroni, S. Peterek, G. Russo, and H. P. Mock, “Juice of new citrus hybrids (Citrus clementina Hort. ex Tan.×C. sinensis L. Osbeck) as a source of natural antioxidants,” Food Chemistry, vol. 117, no. 2, pp. 212–218, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. A. M. Panico, F. Garufi, S. Nitto et al., “Antioxidant activity and phenolic content of strawberry genotypes from Fragaria x ananassa,” Pharmaceutical Biology, vol. 47, no. 3, pp. 203–208, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. M. R. Lauro, L. Crasci, C. Carbone, R. P. Aquino, A. M. Panico, and G. Puglisi, “Encapsulation of a citrus by-product extract: development, characterization and stability studies of a nutraceutical with antioxidant and metalloproteinases inhibitory activity,” LWT-Food Science and Technology, vol. 62, no. 1, pp. 169–176, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. M. R. Lauro, L. Crascí, F. Sansone, V. Cardile, A. M. Panico, and G. Puglisi, “Development and in vitro evaluation of an innovative “dietary flavonoid supplement” on osteoarthritis process,” Oxidative Medicine and Cellular Longevity, vol. 2017, Article ID 7503240, 10 pages, 2017. View at Publisher · View at Google Scholar
  8. F. Salamone, G. Li Volti, L. Titta et al., “Moro orange juice prevents fatty liver in mice,” World Journal of Gastroenterology, vol. 18, no. 29, pp. 3862–3868, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Titta, M. Trinei, and M. StendardoI. Berniakovich, K. Petroni, C. Tonelli et al., “Blood orange juice inhibits fat accumulation in mice,” International Journal of Obesity, vol. 34, no. 3, pp. 578–588, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Sansone, T. Mencherini, P. Picerno, M. d’Amore, R. P. Aquino, and M. R. Lauro, “Maltodextrin/pectin microparticles by spray drying as carrier for nutraceutical extracts,” Journal of Food Engineering, vol. 105, no. 3, pp. 468–476, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. E. B. Rodriguez, M. E. Flavier, D. B. Rodriguez-Amaya, and J. Amaya-Farfán, “Phytochemicals and functional foods. Current situation and prospect for developing countries,” Segurança Alimentar e Nutricional, vol. 13, no. 1, pp. 1–22, 2006. View at Google Scholar
  12. C. Soukoulis, L. Yonekura, H. H. Gan, S. Behboudi-Jobbehdar, C. Parmenter, and I. Fisk, “Probiotic edible films as a new strategy for developing functional bakery products: the case of pan bread,” Food Hydrocolloids, vol. 39, no. 100, pp. 231–242, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. J. R. Paxman, J. C. Richardson, P. W. Dettmar, and B. M. Corfe, “Daily ingestion of alginate reduces energy intake in free-living subjects,” Appetite, vol. 51, no. 3, pp. 713–719, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Houghton, M. D. Wilcox, P. I. Chater, I. A. Brownlee, C. J. Seal, and J. P. Pearson, “Biological activity of alginate and its effect on pancreatic lipase inhibition as a potential treatment for obesity,” Food Hydrocolloids, vol. 49, pp. 18–24, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. M. R. Lauro, C. Carbone, F. Sansone et al., “Innovative oral spray-dried idebenone systems to improve patient compliance,” Drug Development and Industrial Pharmacy, vol. 42, no. 7, pp. 1127–1136, 2016. View at Publisher · View at Google Scholar · View at Scopus
  16. M. R. Lauro, C. Carbone, R. Auditore et al., “A new inclusion complex of amlodipine besylate and soluble β-cyclodextrin polymer: preparation, characterization and dissolution profile,” Journal of Inclusion Phenomena and Macrocyclic Chemistry, vol. 76, no. 1-2, pp. 19–28, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Nasir, S. L. Harikumar, and K. Amanpreet, “Cyclodextrins: an excipient tool in drug delivery: a review,” International Research Journal of Pharmacy, vol. 3, no. 4, pp. 44–50, 2012. View at Google Scholar
  18. L. Crascì, M. R. Lauro, G. Puglisi, and A. Panico, “Natural antioxidant polyphenols on inflammation management: anti-glycation activity vs metalloproteinases inhibition,” Critical Reviews in Food Science and Nutrition, pp. 1–12, 2016. View at Publisher · View at Google Scholar
  19. G. Derosa, P. Maffioli, A. D’Angelo et al., “Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in combined dyslipidemia,” Clinical and Investigative Medicine, vol. 32, no. 2, pp. 124–132, 2009. View at Publisher · View at Google Scholar
  20. F. V. Romeo, G. Ballistreri, S. Fabroni et al., “Chemical characterization of different sumac and pomegranate extracts effective against Botrytis cinerea rots,” Molecules, vol. 20, no. 7, pp. 11941–11958, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. R. L. Rouseff, S. F. Martin, and C. O. Youtsey, “Quantitative survey of narirutin, naringin, hesperidin, and neohesperidin in citrus,” Journal of Agricultural and Food Chemistry, vol. 35, no. 6, pp. 1027–1030, 1987. View at Publisher · View at Google Scholar
  22. O. A. Aiyegoro and A. I. Okoh, “Preliminary phytochemical screening and in vitro antioxidant activities of the aqueous extract of Helichrysum longifolium DC,” BMC Complementary and Alternative Medicine, vol. 10, pp. 21–29, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Rapisarda, F. Fanella, and E. Maccarone, “Reliability of analytical methods for determining anthocyanins in blood orange juices,” Journal of Agricultural and Food Chemistry, vol. 48, no. 6, pp. 2249–2252, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. T. K. Higuchi and A. Connors, “Phase-solubility techniques,” Advances in Analytical Chemistry and Instrumentation, vol. 4, pp. 117–212, 1965. View at Google Scholar
  25. F. Sansone, P. Picerno, T. Mencherini et al., “Flavonoid microparticles by spray-drying: influence of enhancers of the dissolution rate on properties and stability,” Journal of Food Engineering, vol. 103, no. 2, pp. 188–196, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Cao, H. M. Alessio, and R. G. Cutler, “Oxygen-radical absorbance capacity assay for antioxidants,” Free Radical Biology and Medicine, vol. 14, no. 3, pp. 303–311, 1993. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Puglia, V. Cardile, A. M. Panico et al., “Evaluation of monooleine aqueous dispersions as tools for topical administration of curcumin: characterization, in vitro and ex-vivo studies,” Journal of Pharmaceutical Sciences, vol. 102, no. 7, pp. 2349–2361, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Puglia, M. R. Lauro, A. Offerta et al., “Nanostructured lipid carriers (NLC) as vehicles for topical administration of sesamol: in vitro percutaneous absorption study and evaluation of antioxidant activity,” Planta Medica, vol. 83, no. 5, pp. 398–404, 2016. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Derbré, J. Gatto, A. Pelleray, L. Coulon, D. Séraphin, and P. Richomme, “Automating a 96-well microtiter plate assay for identification of AGEs inhibitors or inducers: application to the screening of a small natural compounds library,” Anaytical and Bioanalytical Chemistry, vol. 398, no. 4, pp. 1747–1758, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. D. Edelstein and M. Brownlee, “Mechanistic studies of advanced glycosylation end product inhibition by aminoguanidine,” Diabetes, vol. 41, no. 1, pp. 26–29, 1992. View at Publisher · View at Google Scholar
  31. L. Crascì, P. Vicini, M. Incerti, V. Cardile, S. Avondo, and A. Panico, “2-Benzisothiazolylimino-5-benzylidene-4-thiazolidinones as protective agents against cartilage destruction,” Bioorganic and Medicinal Chemisty, vol. 23, no. 7, pp. 1551–1556, 2015. View at Publisher · View at Google Scholar · View at Scopus
  32. M. D. L. M. Bilbao, C. Andrés-Lacueva, O. Jáuregui, and R. M. Lamuela-Raventos, “Determination of flavonoids in a citrus fruit extract by LC–DAD and LC–MS,” Food Chemistry, vol. 101, no. 4, pp. 1742–1747, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Hillebrand, M. Schwarz, and P. Winterhalter, “Characterization of anthocyanins and pyranoanthocyanins from blood orange [Citrus sinensis (L.) Osbeck] juice,” Journal of Agricultural and Food Chemistry, vol. 52, no. 24, pp. 7331–7338, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. S. R. Georgetti, R. Casagrande, C. R. F. Souza, W. P. Oliveira, and M. J. V. Fonseca, “Spray drying of the soybean extract: Effects on chemical properties and antioxidant activity,” LWT-Food Science and Technology, vol. 41, no. 8, pp. 1521–1527, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. R. R. Araujo, C. C. C. Teixeira, and L. A. P. Freitas, “The preparation of ternary solid dispersions of an herbal drug via spray drying of liquid feed,” Drying Technology, vol. 28, no. 3, pp. 412–421, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. C. R. F. Souza, I. A. Schiavetto, F. C. F. Thomazini, and W. P. Oliveira, “Processing of Rosmarinus officinalis linne extract on spray and spouted bed dryers,” Brazilian Journal of Chemical Engineering, vol. 25, no. 1, pp. 59–69, 2008. View at Publisher · View at Google Scholar
  37. R. L. Carrier, L. A. Miller, and I. Ahmed, “The utility of cyclodextrins for enhancing oral bioavailability,” Journal of Controlled Release, vol. 123, no. 2, pp. 78–99, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. N. Phisut, “Spray drying technique of fruit juice powder: some factors influencing the properties of product,” International Food Research Journal, vol. 19, no. 4, pp. 1297–1306, 2012. View at Google Scholar
  39. M. R. Lauro, F. De Simone, F. Sansone, P. Iannelli, and R. P. Aquino, “Preparations and release characteristics of naringin and naringenin gastro-resistant microparticles by spray-drying,” Journal of Drug Delivery Science and Tecnology, vol. 17, no. 2, pp. 119–124, 2007. View at Publisher · View at Google Scholar
  40. P. Picerno, F. Sansone, T. Mencherini et al., “Citrus bergamia juice: phytochemical and technological studies,” Natural Product Communinication, vol. 6, no. 7, pp. 951–955, 2011. View at Google Scholar
  41. G. P. Panizzon, F. G. Bueno, T. Ueda-Nakamura, C. V. Nakamura, and B. P. Dias Filho, “Preparation of spray-dried soy isoflavone-loaded gelatin microspheres for enhancement of dissolution: formulation, characterization and in vitro evaluation,” Pharmaceutics, vol. 6, no. 4, pp. 599–615, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. A. C. Templeton, S. R. Byrn, R. J. Haskell, and T. E. Prisinzano, Discovering and Developing Molecules with Optimal Drug-Like Properties, Springer, New York, NY, USA, 2015.
  43. B. B. Patel, J. K. Patel, S. Chakraborty, and D. Shukla, “Revealing facts behind spray dried solid dispersion technology used for solubility enhancement,” Saudi Pharmaceutical Journal, vol. 23, no. 4, pp. 352–365, 2015. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Jana, K. Trivedi, R. M. Tallapragada et al., “Characterization of physicochemical and thermal properties of chitosan and sodium alginate after biofield treatment,” Pharmaceutica Analytica Acta, vol. 6, pp. 1–10, 2015. View at Publisher · View at Google Scholar
  45. J. P. Soares, J. E. Santos, G. O. Chierice, and E. T. G. Cavalheiro, “Thermal behavior of alginic acid and its sodium salt,” Eclética Química, vol. 29, no. 2, pp. 57–64, 2004. View at Publisher · View at Google Scholar
  46. M. B. Nieto, “Structure and function of polysaccharide gum-based edible films and coatings,” in Edible films and Coatings for Food Applications, K. C. Huber and M. E. Embuscado, Eds., Springer, New York, NY, USA, 2009. View at Publisher · View at Google Scholar
  47. F. Sansone, A. Rossi, P. Del Gaudio, F. De Simone, R. P. Aquino, and M. R. Lauro, “Hesperidin gastroresistant microparticles by spray-drying: preparation, characterization, and dissolution profiles,” AAPS PharmSciTech, vol. 10, no. 2, pp. 391–401, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. P. Laine, P. Kylli, M. Heinonen, and K. Jouppila, “Storage stability of microencapsulated cloudberry (Rubus chamaemorus) phenolics,” Journal of Agricultural and Food Chemistry, vol. 56, no. 23, pp. 11251–11261, 2008. View at Publisher · View at Google Scholar · View at Scopus
  49. M. Cisse, F. Vaillant, O. Acosta, C. Dhuique-Mayer, and M. Dornier, “Thermal degradation kinetics of anthocyanins from blood orange, blackberry, and roselle using Arrhenius, Eryng, and Ball models,” Journal of Agricultural and Food Chemistry, vol. 57, no. 14, pp. 6285–6291, 2009. View at Publisher · View at Google Scholar · View at Scopus
  50. A. Kirca and B. Cemeroglu, “Degradation kinetics of anthocyanins in blood orange juice and concentrate,” Food Chemistry, vol. 81, pp. 583–587, 2003. View at Publisher · View at Google Scholar · View at Scopus
  51. C. Dhuique-Mayer, M. Tbatou, M. Carail, C. Caris-Veyrat, M. Dornier, and M. J. Amiot, “Thermal degradation of antioxidant micronutrients in citrus juice: kinetics and newly formed compounds,” Journal of Agricultural and Food Chemistry, vol. 55, no. 10, pp. 4209–4216, 2007. View at Publisher · View at Google Scholar · View at Scopus
  52. H. Chaaban, I. Ioannou, I. Chebil et al., “Effect of heat processing on thermal stability and antioxidant activity of six flavonoids,” Journal of Food Processing and Preservation, vol. 41, no. 5, pp. 1–12, 2017. View at Publisher · View at Google Scholar
  53. J. W. BaynesS. R. Thorpe, “Glycoxidation and lipoxidation in atherogenesis,” Free Radical Biology and Medicine, vol. 28, no. 12, pp. 1708–1716, 2000. View at Publisher · View at Google Scholar · View at Scopus
  54. S. I. Yamagishi, N. Nakamura, M. Suematsu, K. Kaseda, and T. Matsui, “Advanced glycation end products: a molecular target for vascular complications in diabetes,” Molecular Medicine, vol. 21, Supplement 1, pp. S32–S40, 2015. View at Publisher · View at Google Scholar · View at Scopus
  55. L. Crascì and A. Panico, “Protective effects of many citrus flavonoids on cartilage degradation process,” Journal of Biomaterilas and Nanobiotechnology, vol. 4, pp. 279–283, 2013. View at Publisher · View at Google Scholar
  56. L. Crascì, L. Basile, A. Panico et al.S. Guccione, “Correlating in vitro target-oriented screening and docking: inhibition of matrix metalloproteinases activities by flavonoids,” Planta Medica, vol. 83, no. 11, pp. 901–911, 2017. View at Publisher · View at Google Scholar
  57. H. I. Park, S. Lee, A. Ullah, Q. Cao, and Q. X. A. Sang, “Effects of detergents on catalytic activity of human endometase/matrilysin 2, a putative cancer biomarker,” Analytical Biochemistry, vol. 396, no. 2, pp. 262–268, 2010. View at Publisher · View at Google Scholar · View at Scopus