Neuroprotective and Cognitive-Enhancing Effects of Microencapsulation of Mulberry Fruit Extract in Animal Model of Menopausal Women with Metabolic Syndrome

Figure 4

Effect of various doses of microencapsulated mulberry fruit extract on the relative density of total P-Erk/Erk in the hippocampus was detected by Western blotting (a) and quantitatively analysis (b). The levels of total P-Erk were normalized against the level of total Erk. Their relative phosphorylation levels (active form) were calculated against those of control normal diet plus vehicle rats. Data are presented as mean ± SEM (/group). value < 0.001, compared to control rats which received normal diet and vehicle, value < 0.05, compared to normal rats which received HCHF diet and vehicle, and value < 0.001, compared to OVX rats which received HCHF and vehicle. ND: normal diet; HCHF: high-carbohydrate high-fat diet; OVX-HCHF: ovariectomized plus high-carbohydrate high-fat diet; MME10, 50, and 250: the microencapsulated mulberry fruit extract at dose of 10, 50, and 250 mg·kg⁻¹ BW, respectively.

(a)

(b)