Oxidative Medicine and Cellular Longevity / 2017 / Article / Tab 2

Research Article

Neuroprotective and Cognitive-Enhancing Effects of Microencapsulation of Mulberry Fruit Extract in Animal Model of Menopausal Women with Metabolic Syndrome

Table 2

The effect of various doses of MME on acetylcholineseterase activity and oxidative stress markers in the hippocampus.

Treatment groupAChE activity (nmol/min·mg protein)MDA (ng/mg protein)SOD (units/mg protein)CAT (units/mg protein)GSH-Px (units/mg protein)

ND + vehicle0.14 ± 0.014.38 ± 1.4159.28 ± 6.40780.07 ± 104.6310.86 ± 1.04
HCHF + vehicle0.17 ± 0.0414.27 ± 2.36aaa47.39 ± 5.86a517.12 ± 53.99aa7.29 ± 0.96aa
OVX + HCHF + vehicle0.43 ± 0.12aaa,bbb11.85 ± 0.85aa14.28 ± 0.82aaa,bbb201.80 ± 12.04aaa,bbb3.64 ± 0.52aaa,bbb
OVX + HCHF + isoflavone 15 mg/kg BW0.19 ± 0.037.05 ± 0.6930.74 ± 2.71411.66 ± 37.814.72 ± 0.42
OVX + HCHF + MME 10 mg/kg BW0.20 ± 0.036.51 ± 0.9838.15 ± 2.53446.31 ± 51.806.94 ± 0.69
OVX + HCHF + MME 50 mg/kg BW0.20 ± 0.034.93 ± 0.6130.07 ± 0.56427.58 ± 15.646.06 ± 0.36
OVX + HCHF + MME 250 mg/kg BW0.26 ± 0.025.06 ± 0.6931.40 ± 1.64464.92 ± 38.167.27 ± 0.43

Data are presented as mean ± SEM (/group). value < 0.05, value < 0.01, value < 0.001, compared to control rats which received normal diet and vehicle, value < 0.001, compared to normal rats which received HCHF diet and vehicle and value < 0.05, value < 0.01, value < 0.001, compared to OVX rats which received HCHF and vehicle.