Neuroprotective and Cognitive-Enhancing Effects of Microencapsulation of Mulberry Fruit Extract in Animal Model of Menopausal Women with Metabolic Syndrome

Table 2

The effect of various doses of MME on acetylcholineseterase activity and oxidative stress markers in the hippocampus.

Treatment group	AChE activity (nmol/min·mg protein)	MDA (ng/mg protein)	SOD (units/mg protein)	CAT (units/mg protein)	GSH-Px (units/mg protein)
ND + vehicle	0.14 ± 0.01	4.38 ± 1.41	59.28 ± 6.40	780.07 ± 104.63	10.86 ± 1.04
HCHF + vehicle	0.17 ± 0.04	14.27 ± 2.36^aaa	47.39 ± 5.86^a	517.12 ± 53.99^aa	7.29 ± 0.96^aa
OVX + HCHF + vehicle	0.43 ± 0.12^aaa,bbb	11.85 ± 0.85^aa	14.28 ± 0.82^aaa,bbb	201.80 ± 12.04^aaa,bbb	3.64 ± 0.52^aaa,bbb
OVX + HCHF + isoflavone 15 mg/kg BW	0.19 ± 0.03	7.05 ± 0.69	30.74 ± 2.71	411.66 ± 37.81	4.72 ± 0.42
OVX + HCHF + MME 10 mg/kg BW	0.20 ± 0.03	6.51 ± 0.98	38.15 ± 2.53	446.31 ± 51.80	6.94 ± 0.69
OVX + HCHF + MME 50 mg/kg BW	0.20 ± 0.03	4.93 ± 0.61	30.07 ± 0.56	427.58 ± 15.64	6.06 ± 0.36
OVX + HCHF + MME 250 mg/kg BW	0.26 ± 0.02	5.06 ± 0.69	31.40 ± 1.64	464.92 ± 38.16	7.27 ± 0.43

Data are presented as mean ± SEM (/group). value < 0.05, value < 0.01, value < 0.001, compared to control rats which received normal diet and vehicle, value < 0.001, compared to normal rats which received HCHF diet and vehicle and value < 0.05, value < 0.01, value < 0.001, compared to OVX rats which received HCHF and vehicle.