Oxidative Medicine and Cellular Longevity / 2017 / Article / Fig 1

Review Article

Unfolded Protein Response of the Endoplasmic Reticulum in Tumor Progression and Immunogenicity

Figure 1

Unfolded protein response (UPR) of the endoplasmic reticulum (ER). UPR is composed of three branches of ER transmembrane sensors, IRE1, PERK, and ATF6. Upon ER stress, BiP is released from the ER sensors and is recruited to misfolded proteins, leading to the activation of UPR. Activated ER sensors transmit the stress signal into the cytosol and nucleus and subsequently operate the coordinated stress response, the UPR.

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