EGCG Prevents High Fat Diet-Induced Changes in Gut Microbiota, Decreases of DNA Strand Breaks, and Changes in Expression and DNA Methylation of Dnmt1 and MLH1 in C57BL/6J Male Mice

Figure 5

Relative CpG methylation status in promotor region of MLH1 in liver of C57BL/6J male mice. Mean methylation data are shown for MLH1 in each intervention group. All methylation data are relative to CD. Error bars represent 95% confidence intervals. In Figure 5(a) significance is shown for CpG 4, 5, and 6. Figure 5(b) shows significant differences in the methylation status of CpG1 (CD = control diet; HFD = high fat diet; CD + EGCG = control diet plus EGCG; HFD + EGCG = high fat diet plus EGCG; stars indicate significance: value ≤ 0.05 and value ≤ 0.01).

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