MicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma

Figure 1

Predicted target genes of miRNA-34a in renal cell carcinoma pathway [KEGG hsa05211]. Disease pathways for each pathological subtype are shown. Hsa-miR-34a-5p can target several genes in RCC pathway. They have complementary regions at their 3UTR, 5UTR, or coding sequence (CDS): HIF-1, VEGF, and TGF-β signaling pathways in clear cell and papillary type II RCC (eosinophilic), as well as MAPK signaling pathway in papillary RCC type I (basophilic). However, candidate genes and the role of miR-34a in oncocytoma and chromophobic RCC pathways are still undetermined. Colored box: miRNA-34a target gene; green color: target on 3UTR sequence; blue color: target on 5UTR sequence; pink color: target on CDS; white box: not predicted target.