MicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma

Figure 3

Gene expression profiling in cancer and normal renal tissues. Data are represented as medians. The box defines upper and lower quartiles (25% and 75%, resp.), and the error bars indicate upper and lower adjacent limits. Expression levels of miR-34a and targets in cancer and normal tissues were normalized to RNU6B and GAPDH, respectively. Fold change was calculated using the delta-delta CT method (2^−ΔΔCT) in comparison to normal renal tissues. The gray dash line represents the expression level of normal renal tissues (equivalent to 1.0). values < 0.05 were considered statistical significant. Mann–Whitney U test was used for comparison. Median and quartile values of patients are noted in red.

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