Oxidative Medicine and Cellular Longevity / 2017 / Article / Fig 3

Review Article

Disrupted Skeletal Muscle Mitochondrial Dynamics, Mitophagy, and Biogenesis during Cancer Cachexia: A Role for Inflammation

Figure 3

Increased muscle use improves skeletal muscle mitochondrial homeostasis in healthy and cachectic conditions. Sedentary behavior or muscle disuse is associated with decreased mitochondrial biogenesis, improper balance of mitochondrial dynamics, dysregulation of autophagy, and mitochondrial dysfunction. Increasing muscle use by reducing sedentary behavior or exercise will increase mitochondrial biogenesis, regulate mitochondrial dynamics, improve autophagic flux, and improve mitochondrial function and ATP efficiency. Overall increased muscle use will lead to skeletal muscle mitochondrial and metabolic homeostasis. The figure was made with Servier Medical Art (http://www.servier.com/Powerpoint-image-bank).

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.