Figure 3: Increased muscle use improves skeletal muscle mitochondrial homeostasis in healthy and cachectic conditions. Sedentary behavior or muscle disuse is associated with decreased mitochondrial biogenesis, improper balance of mitochondrial dynamics, dysregulation of autophagy, and mitochondrial dysfunction. Increasing muscle use by reducing sedentary behavior or exercise will increase mitochondrial biogenesis, regulate mitochondrial dynamics, improve autophagic flux, and improve mitochondrial function and ATP efficiency. Overall increased muscle use will lead to skeletal muscle mitochondrial and metabolic homeostasis. The figure was made with Servier Medical Art (http://www.servier.com/Powerpoint-image-bank).