Hepatoprotective Effect of Polyphenol-Enriched Fraction from Folium Microcos on Oxidative Stress and Apoptosis in Acetaminophen-Induced Liver Injury in Mice

Figure 3

Effects of FMF on APAP-induced liver injury. Mice were intragastrically administered with either PBS or FMF at 100, 200, and 400 mg/kg body weight once daily for 7 consecutive days prior to single administration of APAP (500 mg/kg BW). Mice were killed at 12 h after APAP challenge. Activities of (a) ALT, (b) AST, and (c) LDH were measured in plasma samples by using the commercial kits. Results are shown as ( mice in each group). compared with the control group; ^###, ^## compared with APAP-intoxicated group.

(a)

(b)

(c)