Hepatoprotective Effect of Polyphenol-Enriched Fraction from Folium Microcos on Oxidative Stress and Apoptosis in Acetaminophen-Induced Liver Injury in Mice

Figure 5

Effects of FMF on hepatic levels of MDA, GSH, GSH-Px, SOD, and CAT. Mice were intragastrically administered with either PBS or FMF at 100, 200, and 400 mg/kg body weight once daily for 7 consecutive days prior to single administration of APAP (500 mg/kg BW). Mice were killed at 12 h after APAP challenge. Liver samples were collected, and hepatic homogenates were used for the determination of (a) MDA, (b) GSH, (c) GSH-Px, (d) SOD, and (e) CAT levels by using the commercial kits. Results are shown as ( mice in each group). compared with the control group; ^###, ^##, ^# compared with APAP-intoxicated group.

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