MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis

Table 1

Summary of differentially expressed miRs in relation to OA discussed in the text.

MicroRNA	Targets	Pathway	Model	Reference
miR-9	MMP13	Matrix degradation	Human osteoarthritic chondrocytes	[43]
	SIRT1	Autophagy		[44]
	MCPIP1	Inflammation		[46]
miR-21	lnc GAS5	Apoptosis	Human osteoarthritic chondrocytes	[163]
		Autophagy
miR-23a-3p	SMAD3	TGF-β signal pathway	Human osteoarthritic chondrocytes	[65]
miR-24	p16INK4	Cell senescence Matrix degradation	Human osteoarthritic chondrocytes	[51]
miR-26a	KPNA3	p65 translocation	Human osteoarthritic chondrocytes	[61]
miR-26a-5p	iNOS	NFκB pathway	Human osteoarthritic chondrocytes	[60]
miR-26b	KPNA3	p65 translocation	Human osteoarthritic chondrocytes	[61]
miR-27b	MMP13	Matrix degradation	Human osteoarthritic chondrocytes	[48]
miR-29a	TIMP1	Matrix degradation	Mouse chondrocytes	[63]
	MMP13	Matrix degradation	Mouse chondrocytes
miR-30b	BECN1	Apoptosis; Autophagy	ADTC5 cells	[155]
	ATG5	Matrix degradation
miR-33a	SMAD7	Cholesterol homeostasis	Human osteoarthritic chondrocytes	[62]
	ABCA1
	ApoA1
miR-34a	SIRT1	DNA damage and P53 pathway apoptosis and differentiation	Human osteoarthritic chondrocytes	[52]
	iNOS	Inflammation apoptosis	Rat chondrocyte culture	[53]
miR-127-5p	OPN	Cell proliferation	Human osteoarthritic chondrocytes	[59]
miR-139	MCPIP1	Inflammation	Human osteoarthritic chondrocytes	[47]
miR-140	HDAC4	Chondrocyte hypertrophy osteoblast differentiation	Murine embryos	[38]
	SOX9	Chondrogenesis	Human articular chondrocytes	[39]
	ADAMTS5	Matrix degradation	Mouse chondrocytes	[40]
	TIMP1	Matrix degradation	Mouse chondrocytes	[63]
	MMP13	Matrix degradation	Human osteoarthritic chondrocytes; Mouse chondrocytes	[41, 63]
miR-146a	Bcl-2	Autophagy	C57BL/6J mouse chondrocytes	[158]
	Traf6			[159]
	IRAK1
miR-155	Ulk1	Autophagy	Human osteoarthritic chondrocytes T/C28a2 cells	[160]
	FoxO3
	ATG14
	ATG5
	ATG3
	Gabarapl1
	Map1lc3
miR-449	SIRT1	Autophagy	Human osteoarthritic chondrocytes	[162]
miR-483, miR-22, miR-377, miR-103, miR-16, miR-223, miR-30b, miR-23b, miR-509, miR-29a, miR-140, miR-25, miR-337, miR-210, miR-26a, miR-373	—	—	Human osteoarthritic chondrocytes	[35]
let-7e, miRNA-454, miRNA-885-5p	—	—	Serum OA patients	[36]
miR-16, miR-20b, miR-29c, miR-30b, miR-93, miR-126, miR-146a, miR-184, miR-186, miR-195 miR-345, miR-885-5p	—	—	Plasma OA patients	[37]