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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 3789856, 12 pages
https://doi.org/10.1155/2017/3789856
Research Article

The Correlation between Chemical Structures and Antioxidant, Prooxidant, and Antitrypanosomatid Properties of Flavonoids

1Chemistry Institute, Federal University of Alfenas (Unifal-MG), 37130-001 Alfenas, MG, Brazil
2Human and Natural Sciences Centre, Federal University of ABC (UFABC), 09210-580 Santo André, SP, Brazil
3Parasitology and Pathology Department, Federal University of Alfenas (Unifal-MG), 37130-000 Alfenas, MG, Brazil
4Department of Structural Biology, Federal University of Alfenas (Unifal-MG), 37130-000 Alfenas, MG, Brazil
5Department of Pharmacy, Federal University of Sergipe (UFS-SE), 491000-000 São Cristóvão, SE, Brazil

Correspondence should be addressed to Daniela Aparecida Chagas-Paula; moc.liamg@aluapsagahc.ad

Received 6 January 2017; Revised 23 March 2017; Accepted 20 April 2017; Published 2 July 2017

Academic Editor: Giuseppe Cirillo

Copyright © 2017 João Luiz Baldim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Flavonoids have demonstrated in vivo and in vitro leishmanicidal, trypanocidal, antioxidant, and prooxidant properties. The chemotherapy of trypanosomiasis and leishmaniasis lacks efficacy, presents high toxicity, and is related to the development of drug resistance. Thus, a series of 40 flavonoids were investigated with the purpose of correlating these properties via structure and activity analyses based on integrated networks and QSAR models. The classical groups for the antioxidant activity of flavonoids were combined in order to explain the influence of antioxidant and prooxidant activities on the antiparasitic properties. These analyses become useful for the development of efficient treatments for leishmaniasis and trypanosomiasis. Finally, the dual activity of flavonoids presenting both anti- and prooxidant activities revealed that the existence of a balance between these two features could be important to the development of adequate therapeutic strategies.