The Correlation between Chemical Structures and Antioxidant, Prooxidant, and Antitrypanosomatid Properties of Flavonoids

Figure 4

Results of hierarchical clustering analyses carried out in Gitools 2.3.1 using Euclidean distance and correlation analysis with the most active flavonoids. (a) The most active compounds: fisetin against L. donovani and 7,8-dihydroxyflavone against T. brucei and T. cruzi. (b) The most relevant part of HCA cluster based on pIC₅₀ of all flavonoids. (c) Correlation values of the 40 flavonoids studied with the more active compounds. The intensity of the colors in the heatmap is according to the pIC₅₀ values.

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