Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat

Figure 5

Simvastatin pretreatment inhibits innate immune responses and inflammatory. The mRNA expression of HMGB1 (a), TLR4 (b), CD68 (c), IL-1β (d), IL-6 (e), and ICAM-1(f) were assessed by RT-PCR. The experiments were repeated three times and the data are shown as mean ± SD (; versus NP group, ^# versus DCD-Con group).

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