Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin

Figure 3

Histopathological changes of myocardial tissue (H&E, ×200). (a) Normal control group showing normal myocardial histology, clear transverse striations, and no inflammatory cell infiltration; (b) ISO group showing swelling of obvious myocardial cells, degeneration, loss of transverse striations, and large numbers of invasive inflammatory cells; (c) POS group (propranolol, 10 mg/kg) showing normal myocardial arrangement, clear transverse striations, and slight inflammatory cell infiltration; (d) diosgenin (40 mg/kg) showing myocardial cell swelling, degeneration, unclear horizontal striations, and large numbers of inflammatory cells; (e) diosgenin (60 mg/kg) showing diminished myocardial cell swelling, unclear horizontal striations, and reduced inflammatory cell infiltration; (f) diosgenin (80 mg/kg) showing normal myocardial arrangement, clear transverse striations, and little few inflammatory cells; (g) DN extract (500 mg/kg) showing normal myocardial arrangement, clear transverse striations, and few invasive inflammatory cells.

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