Pharmacological Basis for Use of Armillaria mellea Polysaccharides in Alzheimer’s Disease: Antiapoptosis and Antioxidation
AMPSc improved AD-like behaviors in AlCl3 and D-gal induced AD mice. AMPSc enhanced (a) horizontal movements, but not (b) vertical movements in autonomous activity test, (c) prolonged endurance time in rotarod test, and (d) decreased escape latency time in water maze test in AD mice. Data are expressed as mean ± S.E.M. (). #, ##, and ### versus normal mice (CTRL); , , and versus AD mice. (e) AMPSc reduced apoptotic cell rate in the hippocampus of AD mice determined by TUNEL assay (). Scale bar: 50 μm. AMPS: A. mellea polysaccharides.