Oxidative Medicine and Cellular Longevity / 2017 / Article / Tab 2

Research Article

Pharmacological Basis for Use of Armillaria mellea Polysaccharides in Alzheimer’s Disease: Antiapoptosis and Antioxidation

Table 2

The effects of AMPSc on oxidative statues in serum or hypothalamus in AD mice.

CTRLCTRL + AMPSc (mg/kg)AlCl3 + D-galAlCl3 + D-gal + AMPSc (mg/kg)
10025100

SerumSOD (U/mL)98.6 ± 7.4117.0 ± 5.7#75.9 ± 3.9#110.3 ± 5.3111.5 ± 9.0
GSH-Px (U/mL)249.8 ± 13.1251.3 ± 5.7213.4 ± 10.5##254.4 ± 9.0290.9 ± 16.0
HypothalamusSOD (U/mgprot)44.4 ± 2.155.9 ± 4.6#30.1 ± 2.6##47.0 ± 4.866.1 ± 6.4
GSH-Px (U/mL)326.1 ± 13.9385.0 ± 27.2#282.3 ± 16.4#405.7 ± 31.1501.4 ± 15.2
ROS (FI/mgprot)23087.4 ± 1905.515564.8 ± 3030.9#34418.8 ± 3986.2#14104.1 ± 1260.517877.6 ± 2713.4

Treatment with AMPSc and the levels of SOD, GSH-Px, and ROS in serum and/or hypothalamus were detected via ELISA method. Data are expressed as mean ± S.E.M. (). # and ## versus normal mice (CTRL); and versus AD mice.