Pharmacological Basis for Use of Armillaria mellea Polysaccharides in Alzheimer’s Disease: Antiapoptosis and Antioxidation

Table 2

The effects of AMPSc on oxidative statues in serum or hypothalamus in AD mice.

		CTRL	CTRL + AMPSc (mg/kg)	AlCl3 + D-gal	AlCl3 + D-gal + AMPSc (mg/kg)
			100		25	100
Serum	SOD (U/mL)	98.6 ± 7.4	117.0 ± 5.7^#	75.9 ± 3.9^#	110.3 ± 5.3	111.5 ± 9.0
	GSH-Px (U/mL)	249.8 ± 13.1	251.3 ± 5.7	213.4 ± 10.5^##	254.4 ± 9.0	290.9 ± 16.0
Hypothalamus	SOD (U/mgprot)	44.4 ± 2.1	55.9 ± 4.6^#	30.1 ± 2.6^##	47.0 ± 4.8	66.1 ± 6.4
	GSH-Px (U/mL)	326.1 ± 13.9	385.0 ± 27.2^#	282.3 ± 16.4^#	405.7 ± 31.1	501.4 ± 15.2
	ROS (FI/mgprot)	23087.4 ± 1905.5	15564.8 ± 3030.9^#	34418.8 ± 3986.2^#	14104.1 ± 1260.5	17877.6 ± 2713.4

Treatment with AMPSc and the levels of SOD, GSH-Px, and ROS in serum and/or hypothalamus were detected via ELISA method. Data are expressed as mean ± S.E.M. (). ^# and ^## versus normal mice (CTRL); and versus AD mice.