Flavonoids as Putative Inducers of the Transcription Factors Nrf2, FoxO, and PPARγ

Table 1

Correlation coefficients with values. Significant correlations are printed in bold () and correlations printed in italics show a trend (). We could not find any correlation between the antioxidant capacity as measured by the FRAP or ABTS assay and the luciferase assays. The total number of hydroxy groups in the molecule and especially the number of hydroxy groups in the flavonoid B-ring correlated strongly with the outcome in the FRAP and ABTS assays. Furthermore, ARE- and FHRE-activation correlated strongly with each other, and, albeit to a lesser extent, with PPARγ-activation.

Pearson correlation coefficients ( values)	Total OH	OH in A ring	OH in B ring	OH in C ring	PPAR-UAS activation	FHRE activation	ARE activation	FRAP
ABTS	0.59 (0.06)	−0.21 (0.59)	0.73 (0.03)	0.52 (0.15)	0.05 (0.88)	0.09 (0.79)	0.45 (0.16)	0.98 (<0.0001)
FRAP	0.73 (0.01)	−0.21 (0.59)	0.82 (0.001)	0.52 (0.15)	0.12 (0.72)	0.14 (0.70)	0.46 (0.16)
ARE activation	0.43 (0.19)	−0.31 (0.42)	0.64 (0.06)	0.35 (0.36)	0.64 (0.04)	0.85 (0.001)
FHRE activation	0.20 (0.56)	−0.31 (0.42)	0.37 (0.33)	−0.35 (0.36)	0.67 (0.03)
PPAR-UAS activation	0.26 (0.44)	−0.31 (0.42)	0.27 (0.48)	0.17 (0.66)