The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain

Figure 2

Ethanol oxidation by CYP2E1 results in an increase of ROS and oxidative stress. Ethanol can induce the expression/activity of CYP2E1 resulting in an increase of ROS and cellular damage. Increased ROS levels damage biomolecules such as lipid, protein, DNA, and mitochondria, starting a feedback cycle of ROS production-damage. ALD: aldehyde dehydrogenase; CYP2E1: cytochrome isoform 2E1; ^•OH: hydroxyl radical; : superoxide anion radical; H₂O₂: hydrogen peroxide; Fe²⁺: ferrous iron; NADPH: nicotinamide adenine dinucleotide phosphate (oxidized form); NADP⁺: nicotinamide adenine dinucleotide phosphate (reduced form).