The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain

Table 1

CYP2E1 brain distribution in rat, human, and monkey brains.

Species	Region	CYP2E1	Detection method	Reference
Rat	Olfactory lobe	mRNA	RT-PCR	[37]
			in situ hybridization	[45]
		Protein	Western blot	[39, 40, 43]
		Activity	HPLC chlorzoxazone method	[45, 152]
	Cortex	mRNA	In situ hybridization	[45]
		Protein	Immunohistochemistry	[11, 43]
		Activity	HPLC chlorzoxazone method	[45, 152]
	Hippocampus	mRNA	In situ hybridization	[41]
		Protein	Immunohistochemistry	[11, 38]
		Activity	HPLC chlorzoxazone method	[40, 41]
	Cerebellum	mRNA	In situ hybridization	[45]
		Protein	Immunohistochemistry	[11, 43]
		Activity	HPLC chlorzoxazone method	[45, 152]
	Striatum	mRNA	In situ hybridization	[45]
		Activity	HPLC chlorzoxazone method	[45, 152]
	Thalamus	mRNA	In situ hybridization	[45]
Human	Cortex	Protein	Immunohistochemistry	[11]
		mRNA	In situ hybridization, PCR	[41, 48]
		Activity	HPLC chlorzoxazone method	[41]
	Cerebellum	Protein	Immunohistochemistry	[11]
		mRNA	In situ hybridization, PCR	[41, 48]
		Activity	HPLC chlorzoxazone method	[41]
	Hippocampus	Protein	Immunohistochemistry	[11]
		mRNA	In situ hybridization	[41]
		Activity	HPLC chlorzoxazone method	[41]
	Eye	mRNA	RT-PCR	[50]
	Pons	mRNA	PCR	[48]
		Activity	HPLC chlorzoxazone method	[41]
	Substantia nigra	mRNA	PCR	[48]
	Striatum	Activity	HPLC chlorzoxazone method	[41]
	Thalamus	Activity	HPLC chlorzoxazone method	[41]
Human prenatal brain		Protein	Western blot	[49]
		mRNA	RT-PCR	[49]
		Activity	HPLC nitrophenol method	[49]
Monkey	Cerebellum	Protein	Immunohistochemistry	[44]
	Cortex	Protein	Immunohistochemistry	[44]
	Hippocampus	Protein	Immunohistochemistry	[44]
	Substantia nigra	Protein	Immunohistochemistry	[44]